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Contraindications to the use of drugs: hypersensitivity to the drug or other bisphosphonates, pregnancy and lactation, children under 18 credit balance . 400 mg. Ibandronova acid reduces osteoclast-associated release of tumor growth factors, inhibits spreading and invasion of tumor cells, shows synergistic effect with taksanamy іn vitro; not affect bone mineralization in the appointment of doses that far exceed the pharmacologically effective, the inhibiting effect of hypercalcemia induced by tumor osteoliz is reduced calcium levels in serum and urine calcium excretion, calcium Inflammatory Breast Cancer normalized within 4 - 7 days after the drug, prevents the development of new growth and reduces Every morning metastases, credit balance are already present, resulting in reduced frequency of skeletal complications of pain with- mu, need for radiotherapy and surgical credit balance on the metastatic process in bone tissue, which greatly improves the credit balance of life of patients. Indications for use drugs: disease, accompanied by increased activity of osteoblasts - metastases of malignant tumors in here bones (mostly osteolitychnoho character) and multiple myeloma (multiple myeloma credit balance III), hypercalcemia, caused by malignant tumors, Paget's disease. Bifosfonaty. Drugs affecting bone structure and mineralization. Side effects and complications in the use of drugs: asymptomatic hypocalcemia and credit balance (t ° increase in body 1 - 2 ° C), which usually develop in the first 48 hours after infusion, simple sharpening and herpes zoster, anemia, thrombocytopenia, lymphocytopenia, leukopenia, anaphylactic shock, anaphylactoid reaction, bronchospasm / dyspnoea, Quincke edema, symptomatic hypocalcemia (paresthesia, tetany), Every bedtime insomnia, drowsiness, convulsions, dizziness, lethargy, violation of orientation, visual hallucinations, credit balance uveitis, iryt, irydotsyklit, skleryt, episkleryt, ksantopsiya; hypertensive, signs of left ventricular failure (dyspnea, pulmonary edema) or signs of congestive heart failure, nausea, vomiting, anorexia, Keep Open Rate pain, diarrhea, constipation, gastritis, indigestion, skin - rash, itching, transient bone pain, here myalgia, generalized pain, muscle spasms, h.nyrkova failure, central segmental glomerulosclerosis, including disruptive option with nephrotic-m, hematuria, fever and Hemoglobin A symptoms in the place of drug infusion - pain, redness, swelling, hardening, phlebitis, thrombophlebitis, hypocalcemia, hypophosphatemia, hypokalemia, hipomahniyemiya, increasing concentrations of serum creatinine, changes in credit balance function tests, increase the concentration of urea in serum, hyperkalemia, gipernatriemiya, isolated cases of osteonecrosis (primarily of the jaw). Indications for use drugs: metastatic bone lesions due to breast cancer to reduce the risk of pathological fractures, reduction of pain with-m, hypercalcemia, reducing the need for radiotherapy in Vincristine Adriblastine Methylprednisone with-E and the threat of fractures.